Vitamin B6 is a water-soluble vitamin that was isolated as a pure form of the vitamin in 1938, it is found in 3 forms called pyridoxine, pyridoxamine and pyridoxal. Pyridoxal phosphate is an important coenzyme in the transamination, decarboxylation and deamination reactions of amino acids. Pyroxidine is essential for the normal breakdown of proteins, carbohydrates and fats. Helps convert the amino acid tryptophan into niacin and serotonin. It is considered essential for the normal functioning of the brain, nervous and muscular system. It is important for the production of antibodies and red blood cells and is also involved in the biosynthesis of porphyrins.

Vitamin B6 deficiency can cause neurological disorders, dermatitis and gastroenteritis. In addition, it has been associated with the occurrence of anemia and mucosal lesions, such as seborrhea. It can also lead to depression, seizures, oily scaly skin and sores in the mouth.

Melatonin is a neurohormone produced by the brain and specifically by the epiphysis, from the amino acid tryptophan. It helps the body know when it is time to go to bed and when it is time to wake up. The synthesis and secretion of melatonin in the brain are activated by darkness and inactivated by light. This fact shows that the hormone is involved in the twenty-four hour rhythm of the human body and in the regulation of various bodily functions. The concentration of melatonin in the blood reaches its highest levels just before bedtime. It has antioxidant properties and increases the production of type T lymphocytes which is a key pillar of the immune system.

Nature's Plus Co-Mel contains the exact levels of vitamin B6 and melatonin that are considered essential for the body and therefore, is a useful aid in the treatment of insomnia and acts against the disruption of the biological cycle that occurs when people travel to different time zones ( jet lag).