Use in the evening: in clean skin on the face and neck, with light massage to be absorbed by the skin.

For morning use: it can be applied under day cream, or under sunscreen with SPF 30.
Leave the cream for 2-4 minutes to be absorbed by the skin. There may be a slight squeeze after every application. This is perfectly normal and is due to the action of the product.
It usually takes six to eight weeks of normal use to see a remarkable difference.