D-Mannose formula is a dietary supplement containing the monosaccharide D-mannose.

What is D-Mannose?
D-mannose is a simple sugar, which has a special contribution to metabolism, through its role in the glycosylation of certain proteins. D-mannose is rapidly absorbed and reaches the peripheral organs in about 30 minutes and is then excreted by the urinary system. It cannot be converted to glycogen, therefore it is not stored in the body. It attaches to lectins and thus prevents the attachment of pathogens to the walls of the bladder.

Action mechanism

Its mechanism of action is expressed through inhibition of adhesion of the FimH surface protein. By the direct binding of FimH to D-mannose bound to a vector protein, which is responsible for receptor specificity.

The first adhesion step involves the binding of mannose-sensitive FimH to the epithelium. The bladder wall is coated with various mannose-glycosylated proteins, such as Tamm-Horsfall protein (THP), which directly interferes with the adhesion of germs to the mucosa. Tamm-Horsfall protein (THF) can bind to E. coli with a specific bond, which can be inhibited by exogenous D-mannose.

 By inhibiting the adhesion of germs to the urinary tract epithelium, D-mannose mimics the function of the urinary tract epithelial barrier.