The Benfotiamine is fat-soluble form of vitamin B1 (thiamine), which supports and helps the healthy metabolism of blood sugar and thereby helps to protect cells and tissues of the body from excessive glycosylation and oxidative stress. The Benfotiamine activates glucose metabolism and helps maintain normal values ​​of the blood sugar. It also reduces the excessive glycosylation toxicity prevents blood glucose and corrects the damage of endothelial cells caused due to excessive glycosylation. Finally, promotes good health and function of the nerves, kidneys, eyes, heart and blood vessels. 
Transosketolasi The enzyme, which is important for the metabolism of sugars to function properly requires a cofactor, and the help this gives thiamine VI. But that is water soluble, so less available inside the cells. Therefore Benfotiamine, which is fat-soluble, it can easily penetrate inside cells and help transosketolasi since it is more bioavailable. 
In various investigations demonstrated that helps Benfotiamine and effectively increases the action of trafsosketolasis cell cultures by 300% compared with the thiamine helps 20%. 
This activation is necessary to stop three of the four metabolic pathways that lead to damage and destruction of vessels. The Benfotiamine also stops the activation of the replicative factor known as nuclear factor Kappa B (NF-kB), which is involved in many inflammatory processes.