Cannabinoids have been used for thousands of years to improve people's quality of life. Their administration contributes to the relief of physical and mental difficulties, as well as to keeping the body in balance. The effect of cannabinoids can vary from person to person, and depends on their type and quality, as well as the route of administration. Their mode of action is linked to the functioning of the Endocannabinoid System (ECS).    The CSF is a complex network of receptors, signaling molecules (endocannabinoids) and enzymes.