Methylcobalamin (B12) plays an important role in the formation of red blood cells, in the brain and nervous system, and in the regulation of the immune system. Cobalamin deficiency can cause megaloblastic anemia, peripheral neuropathy, irritability, dementia, depression, psychosis, increased risk of myocardial infarction and stroke.

Evidence suggests that methylcobalamin has metabolic benefits and potential therapeutic applications that are not available from other forms of vitamin B12. Although cyanocobalamin is the most common form of vitamin B12 in supplements, it must be converted to methylcobalamin or adenosylcobalamin.

Eating deficiencies, enzyme defects and tissue abnormalities may reduce the body's ability to synthesize these active forms. Methylcobalamin participates in the synthesis of methionine by homocysteine. This helps reduce homocysteine ​​levels, which is recognized as a dangerous factor for cardiovascular disease. It is also important for the formation of dopamine and serotonin neurotransmitters.

The biologically active form of NOW Methyl B12 is a powerful donor of methyl groups in the myelin shell, which insulates nerve fibers and regenerates damaged neurons. Recent evidence suggests that methylcobalamin may be beneficial to patients with neuropathies.